Tetracycline as a bone targeted agent in prevention of steroid-enhanced osteonecrosis induced by Shwartzman reaction 骨靶向药物四环素预防激素增强Shwartzman反应骨坏死的实验研究
The model of Yingfen and Xuefen syndromes of epidemic febrile disease was made in rabbits by endotoxin to induce generalized Shwartzman reaction. 本实验用内毒素诱发家兔全身性施瓦茨曼反应制成温病营血分证模型,并对其实质进行研究。
Objective To investigate the effects of tetracycline on steroid_enhanced osteonecrosis induced by shwartzman reaction in rabbit model. 目的对四环素预防激素增强Shwartzman反应骨坏死的实验效果进行初步观察。
However, LPS also shows strong toxic reaction ( Shwartzman reaction, pyrogenic reaction, etc) that hinders its clinical application. Many researchers have been committed to the toxicity attenuation of LPS. 但是LPS同时表现出强烈的毒性反应(Shwartzman反应,热原性等),因此阻碍了它在临床上的应用,所以许多研究者一直致力于LPS的减毒研究。